USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PRS6B_HUMAN USC-OGP 2-DE database:  PRS6B_HUMAN PRS6B_HUMAN General information about the entry View entry in simple text format Entry name PRS6B_HUMAN Primary accession number P43686 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=26S protease regulatory subunit 6B; AltName: Full=26S proteasome AAA-ATPase subunit RPT3; AltName: Full=MB67-interacting protein; AltName: Full=MIP224; AltName: Full=Proteasome 26S subunit ATPase 4; AltName: Full=Tat-binding protein 7; Short=TBP-7;. Gene name Name=PSMC4 Synonyms=MIP224, TBP7 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0383: pI=5.05; Mw=47945 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0682: pI=5.05; Mw=49064 Cross-references UniProtKB/Swiss-Prot P43686; PRS6B_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRS6B_HUMAN Primary accession number P43686 Secondary accession number(s) Q96FV5 Q9UBM3 Q9UEX3 Sequence was last modified on  May 10, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 177) Name and origin of the protein Description RecName: Full=26S protease regulatory subunit 6B; AltName: Full=26S proteasome AAA-ATPase subunit RPT3; AltName: Full=MB67-interacting protein; AltName: Full=MIP224; AltName: Full=Proteasome 26S subunit ATPase 4; AltName: Full=Tat-binding protein 7; Short=TBP-7; Gene name Name=PSMC4 Synonyms=MIP224, TBP7 Encoded on Name=PSMC4; Synonyms=MIP224, TBP7 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF038965; AAC26843.1; -; mRNA EMBL U27515; AAC99817.1; -; mRNA EMBL AF020736; AAC32612.1; -; mRNA EMBL BT007232; AAP35896.1; -; mRNA EMBL AC007842; AAD39267.1; -; Genomic_DNA EMBL BC000343; AAH00343.1; -; mRNA EMBL BC010396; AAH10396.1; -; mRNA EMBL BC014488; AAH14488.1; -; mRNA CCDS CCDS12547.1; -. [P43686-1]; . CCDS CCDS46076.1; -. [P43686-2]; . RefSeq NP_006494.1; NM_006503.3. [P43686-1]; . RefSeq NP_694546.1; NM_153001.2. [P43686-2]; . UniGene Hs.211594; -; . PDB 2DVW; X-ray; 2.30 A; B=337-418 PDB 5GJQ; EM; 4.50 A; K=1-418 PDB 5GJR; EM; 3.50 A; K/y=1-418 PDB 5L4G; EM; 4.02 A; K=1-418 PDB 5T0C; EM; 3.80 A; AD/BD=1-418 PDB 5T0G; EM; 4.40 A; D=1-418 PDB 5T0H; EM; 6.80 A; D=1-418 PDB 5T0I; EM; 8.00 A; D=1-418 PDB 5T0J; EM; 8.00 A; D=1-418 PDBsum 2DVW; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P43686; -; . SMR P43686; -; . BioGrid 111677; 124; . DIP DIP-29274N; -; . IntAct P43686; 44; . MINT MINT-5004247; -; . STRING 9606.ENSP00000157812; -; . iPTMnet P43686; -; . PhosphoSitePlus P43686; -; . SwissPalm P43686; -; . BioMuta PSMC4; -; . DMDM 20532409; -; . OGP P43686; -; . EPD P43686; -; . MaxQB P43686; -; . PaxDb P43686; -; . PeptideAtlas P43686; -; . PRIDE P43686; -; . DNASU 5704; -; . Ensembl ENST00000157812; ENSP00000157812; ENSG00000013275. [P43686-1]; . Ensembl ENST00000455878; ENSP00000413869; ENSG00000013275. [P43686-2]; . Ensembl ENST00000629691; ENSP00000487367; ENSG00000281221. [P43686-1]; . Ensembl ENST00000630857; ENSP00000485851; ENSG00000281221. [P43686-2]; . GeneID 5704; -; . KEGG hsa:5704; -; . UCSC uc002omq.5; human. [P43686-1]; . CTD 5704; -; . DisGeNET 5704; -; . GeneCards PSMC4; -; . HGNC HGNC:9551; PSMC4; . HPA HPA002044; -; . HPA HPA005471; -; . MIM 602707; gene; . neXtProt NX_P43686; -; . OpenTargets ENSG00000013275; -; . PharmGKB PA33896; -; . eggNOG KOG0727; Eukaryota; . eggNOG COG1222; LUCA; . GeneTree ENSGT00550000074962; -; . HOGENOM HOG000225143; -; . HOVERGEN HBG000109; -; . InParanoid P43686; -; . KO K03063; -; . OMA GYKNNTK; -; . OrthoDB EOG091G07NC; -; . PhylomeDB P43686; -; . TreeFam TF106227; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMC4; human; . EvolutionaryTrace P43686; -; . GeneWiki PSMC4; -; . GenomeRNAi 5704; -; . PRO PR:P43686; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000013275; -; . CleanEx HS_PSMC4; -; . ExpressionAtlas P43686; baseline and differential; . Genevisible P43686; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0031597; C:cytosolic proteasome complex; IBA:GO_Central; . GO GO:0016234; C:inclusion body; IEA:Ensembl; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0031595; C:nuclear proteasome complex; IBA:GO_Central; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0022624; C:proteasome accessory complex; ISS:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0008540; C:proteasome regulatory particle; base subcomplex; IBA:GO_Central GO GO:0045202; C:synapse; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; TAS:ProtInc; . GO GO:0036402; F:proteasome-activating ATPase activity; IBA:GO_Central; . GO GO:0017025; F:TBP-class protein binding; IBA:GO_Central; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0001824; P:blastocyst development; IEA:Ensembl; . GO GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IBA:GO_Central; . GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IBA:GO_Central; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006508; P:proteolysis; TAS:ProtInc; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.40.50.300; -; 1; . InterPro IPR005937; 26S_Psome_P45; . InterPro IPR003593; AAA+_ATPase; . InterPro IPR003959; ATPase_AAA_core; . InterPro IPR003960; ATPase_AAA_CS; . InterPro IPR027417; P-loop_NTPase; . Pfam PF00004; AAA; 1; . SMART SM00382; AAA; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01242; 26Sp45; 1; . PROSITE PS00674; AAA; 1; .

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